Drug Safety
A number of drugs, including anti-depressives, and nonsteroidal anti-inflammatory drugs including Cox-II inhibitors, have appeared in the media because of new concerns involving side-effects. The anti-depressives were associated with an increased risk of suicide, while concerns were raised regarding an increased risk of heart attacks and strokes with aspirin-like medicines, including Vioxx.
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Artificial Intervertebral Disc
In late October, 2004, the FDA approved the first artificial disc replacement in the United States. The approval occurred after a study matching spinal fusion with a metal spacer versus the disc replacement demonstrated similar levels of improvement. The overall success rate at 2 years was 64% with the disc replacement and 55% with the spinal fusion. Improvement was measured by a decrease in pain and function, and no major complications including nervous system damage. Failure to achieve significant pain relief occurred in 26% of the disc replacement and 38% of the fusion group. Although the artificial disc may offer some benefits compared to spinal fusion, this new device is appropriate for only a very specific group of patients.
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